It is very simple to reach the Masseria Bandino both by plane (Brindisi airport), as well as by train and car.

You can reach Lecce from the main Italian cities by railway and then get a Sud-Est Railway train from Lecce to Otranto.

If you travel by car, you have to leave the motorway at Bari Nord and then take the dual-carriage-way to Brindisi-Lecce. When you reach Lecce, follow the road signs for Otranto